Recentes avanços nas aplicações biomédicas de dendrímeros de poli(amidoamina) (pamam) (2019)
- Authors:
- USP affiliated author: ARAUJO, RENAN VINICIUS DE - FCF
- School: FCF
- Subjects: POLÍMEROS (MATERIAIS); NANOTECNOLOGIA
- Language: Português
- Abstract: Abstract: Dendrimers are nanoscopic compounds, which are monodispersed, and they are generally considered as homogeneous. PAMAM (polyamidoamine) was introduced in 1985, by Donald A. Tomalia, as a new class of polymers, named ‘starburst polymers’. This important contribution of Professor Tomalia opened a new research field involving nanotechnological approaches. From then on, many groups have been using PAMAM for diverse applications in many areas, including biomedical applications. The possibility of either linking drugs and bioactive compounds, or entrapping them into the dendrimer frame can improve many relevant biological properties, such as bioavailability, solubility, and selectivity. Directing groups to reach selective delivery in a specific organ is one of the advanced applications of PAMAM. In this review, structural and safety aspects of PAMAM and its derivatives are discussed, and some relevant applications are briefly presented. Emphasis has been given to gene delivery and targeting drugs, as advanced delivery systems using PAMAM and an incentive for its use on neglected diseases are briefly mentioned
- Imprenta:
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ABNT
ARAÚJO, Renan Vinicius de e GIAROLLA, Jeanine. Recentes avanços nas aplicações biomédicas de dendrímeros de poli(amidoamina) (pamam). 2019. Trabalho de Conclusão de Curso (Graduação) – Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, 2019. Disponível em: https://bdta.abcd.usp.br/directbitstream/2155ecbb-047f-4007-90d8-add04dd06990/3055312.pdf. Acesso em: 19 abr. 2024. -
APA
Araújo, R. V. de, & Giarolla, J. (2019). Recentes avanços nas aplicações biomédicas de dendrímeros de poli(amidoamina) (pamam) (Trabalho de Conclusão de Curso (Graduação). Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo. Recuperado de https://bdta.abcd.usp.br/directbitstream/2155ecbb-047f-4007-90d8-add04dd06990/3055312.pdf -
NLM
Araújo RV de, Giarolla J. Recentes avanços nas aplicações biomédicas de dendrímeros de poli(amidoamina) (pamam) [Internet]. 2019 ;[citado 2024 abr. 19 ] Available from: https://bdta.abcd.usp.br/directbitstream/2155ecbb-047f-4007-90d8-add04dd06990/3055312.pdf -
Vancouver
Araújo RV de, Giarolla J. Recentes avanços nas aplicações biomédicas de dendrímeros de poli(amidoamina) (pamam) [Internet]. 2019 ;[citado 2024 abr. 19 ] Available from: https://bdta.abcd.usp.br/directbitstream/2155ecbb-047f-4007-90d8-add04dd06990/3055312.pdf
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